Expeditionary Fighting Vehicle Research Paper Example | Topics and Well Written Essays - 1500 words

Expeditionary Fighting Vehicle - Research Paper Example This essay discusses the Expeditionary Fighting Vehicle, that is aimed for two main functions. First, transport a Marine Corps Rifle Squad from the sea to the shore and second - to provide armor operational capabilities on land. The assault vehicles are transported in ships and can be launched beyond the visual horizon. The visual horizon is the visible limit to detect presence of ships at sea from the shore line. This distance is translated as 25 kilometers as per the planning and development of the program. The supporters of this program argue and justify the flexibility that the assault vehicles provide to the Marines. The over the horizon launch capability provides protection to the amphibious ships till 25 kilometers from the shore. Furthermore, once deployed the vehicles have enough speed to make enemy tracking and defensive measures in the sea difficult. The time to reach the shore has also been shortened. The researcher then concluds that Expeditionary Fighting Vehicle was an ambitious program that provided lethal capabilities and its design matured over years. The program, however, could not prove its reliability and did not come up to the desired standards of the Marine Corps. The in service Amphibious Assault Vehicle has gone through various life extension programs and upgraded over time to meet operational requirement. The termination of the program was a serious setback to the Marine Corps and its replacement must provide with upgraded hardware to cope with the evolving Marine Corps strategy and doctrines.

Phrmaceutical Formulation Essay Example | Topics and Well Written Essays - 3000 words

Phrmaceutical Formulation - Essay Example It has a wide range of applications, like, levosalbutamol inhalers have been designed to help in the treatment of asthma. Pulmonary drug delivery can be used to administer a vaccine like in the case of currently inhaled measles vaccine given by nebilizer. (Molema, 2001 pg 16) Also it can be used to give medication to infants and young children who have a small tidal volume and low inspiratory flow rates by the use of a baby mask which normally is attached to spacer. (Perry, 2012 pg 25)It has been used to treat lung cancer by the means of inhaled chemotherapy which has proven to be a logical approach and also it is used on patients who are very ill who cannot withstand any more pain by inhaling opioids such as morphine and fentanyl. (Sigmund, 2009 pg10) Drugs used in pulmonary drug delivery have multi-component powders with mucoactive compounds and anti-asthmatic medicines bound together in a single particle because of the mucus layer covering the airways of the tracheobronchial struc ture. (Friebel, 2010 pg 20)The substances used in the inhalers must dissolve 100% so as not to block the air gaps to avoid suffocation. (Le, 2001 pg 37) Been affected by the rapid change of technology due to great inventions pharmaceutical industries had to do some research to come up with more efficient drug delivery system like drug powder inhalers. (Zeng, 2001 pg 8) Although drug powder inhalers has greatly boosted the pharmaceutical companies there are challenges that are experienced during its formulation like the cohesive ,adhesive property of drug and carrier aggregation, particle size , morphology of the drug and carrier aerosolization performance and powder formulation properties. (Koning, 2001 pg 40)One of the challenges in pharmaceutical industries is to characterize their various physical behaviors; here the concern is mainly focused on the study of the relations relating the properties of the grain to those of the powder bed. (Wang, 2012 pg 44)The goal is thus to be abl e to control, analyze and improve the manufacturing processes of the powder. (Talton, 1999 pg 60) To improve the aerosolization performance of drug powder inhalers, varieties of carrier and carrier types have to be sampled and studied so as to come up with the best, and the drug ratios are prepared by spray-drying so as to improve the efficiency of the drying procedure and the characterized at last. Again to improve aerosolization two critical physical properties which are the particle size and flowability has to be keenly observed where the particle size should be around 5-6   Ã‚ µm and the angle of repose to be within the ranges of 43 °Ã¢â‚¬â€œ52 ° for the flowability to boost the aerosolization. If this is done well the aerosolization performances can be improve greatly. Cohesion forces of particles used in dry powder formulation is a great nuisance to inhalers because it reduces powder flow and hinders accurate metering hence needs to reduce it and this can be achieved by blending the active pharmaceutical ingredient with a larger inert carrier so as to reduce the high cohesion forces that are normally between the micron sized active pharmaceutical ingredient particles. Adhesion forces are also of great concern in dry powder inhalers because if not catered for they make the patient to find it difficult to deliver the drug from the inhaler to his or her system hence it must be overcome or reduced by great magnitude so as to allow liberation of drug from the device with minimal energy from the patient. The particle size is a challenge in drug powder inhalation